Depression Drug Unwanted Effects Including Body Weight, Blood Pressure Fluctuations Vary Depending on Medication

• A large latest study found that the adverse reactions of antidepressant medications differ substantially by drug.
• Some pharmaceuticals resulted in reduced body weight, whereas others led to added mass.
• Pulse rate and blood pressure furthermore varied notably across treatments.
• Those experiencing continuing, intense, or troubling side effects must consult a medical provider.

Latest research has revealed that depression drug unwanted effects may be more varied than once assumed.

The extensive investigation, released on the 21st of October, examined the impact of antidepressant medications on more than 58,000 individuals within the beginning eight weeks of commencing medication.

The investigators examined 151 studies of 30 medications typically employed to address depression. While not everyone experiences unwanted effects, some of the most prevalent recorded in the research were fluctuations in weight, BP, and metabolic parameters.

Researchers observed notable differences across antidepressant medications. For instance, an 60-day treatment period of one medication was connected with an average decrease in mass of approximately 2.4 kilos (approximately 5.3 pounds), whereas another drug individuals gained almost 2 kg in the identical duration.

There were also, marked fluctuations in heart function: one antidepressant was likely to reduce cardiac rhythm, while another medication raised it, creating a difference of about 21 heartbeats per minute among the two medications. BP differed also, with an 11 mmHg difference observed across one drug and another medication.

Healthcare experts observed that the research's results aren't recent or startling to psychiatrists.

"Clinicians have long recognized that various depression drugs range in their effects on weight, BP, and additional metabolic indicators," one expert stated.

"However, what is significant about this study is the comprehensive, relative measurement of these differences across a wide spectrum of physical indicators using findings from in excess of 58,000 individuals," the professional added.

The research delivers robust proof of the extent of adverse reactions, several of which are more frequent than different reactions. Common depression drug side effects may encompass:

• digestive issues (queasiness, bowel issues, blockage)
• intimacy issues (decreased libido, anorgasmia)
• mass variations (gain or reduction, depending on the medication)
• sleep disturbances (insomnia or sedation)
• mouth dryness, sweating, head pain

Additionally, less frequent but therapeutically relevant adverse reactions may comprise:

• increases in BP or heart rate (notably with SNRIs and certain tricyclic antidepressants)
• hyponatremia (notably in older adults, with selective serotonin reuptake inhibitors and SNRIs)
• elevated hepatic parameters
• QTc extension (risk of arrhythmia, notably with one medication and certain tricyclic antidepressants)
• diminished feelings or indifference

"One thing to remember regarding this matter is that there are multiple varying types of antidepressants, which result in the varying unwanted pharmaceutical reactions," a different specialist explained.

"Additionally, depression treatments can affect each patient variably, and negative side effects can vary according to the particular pharmaceutical, amount, and personal considerations such as body chemistry or simultaneous health issues."

Although certain adverse reactions, including changes in rest, appetite, or stamina, are reasonably frequent and frequently improve with time, different reactions may be less typical or continuing.

Antidepressant adverse reactions may differ in severity, which could warrant a adjustment in your treatment.

"An adjustment in antidepressant medication may be necessary if the individual suffers continuing or unbearable side effects that do not improve with duration or supportive care," a specialist said.

"Additionally, if there is an emergence of recent medical issues that may be worsened by the existing treatment, such as elevated BP, arrhythmia, or significant weight gain."

You may furthermore think about speaking with your healthcare provider concerning any lack of significant enhancement in depression-related or worry indicators after an sufficient evaluation duration. The appropriate testing period is usually 4–8 weeks at a effective dosage.

Personal inclination is also significant. Some individuals may prefer to avoid particular unwanted effects, such as sexual problems or {weight gain|increased body weight|mass addition